The reason for generalized itching with liver disease is not well understood, other than the apparent link with obstructed bile flow. Bile salts, chemicals closely related to bile, are deposited in your skin when bilirubin levels rise and are thought to be the primary cause of itching. Detailed research and explanations are difficult when a symptom like itching occurs with multiple different diseases, is experienced somewhat differently by each individual and responds to different treatments in different cases.
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